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Biocomparison Study

NCT01638182 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 81

Last updated 2012-07-11

No results posted yet for this study

Summary

The effects of two vitamin K-forms on carboxylation of the vitamin K-dependent proteins osteocalcin and matrix-gla protein will be compared after supplementing these vitamins in a nutritional dose range.

The investigators hypothesized that MK-7 is more effective than K1 at a dose comparable to the RDA of vitamin K.

Conditions

  • Bone Health
  • Vascular Health

Interventions

DIETARY_SUPPLEMENT

Placebo

27 participants received for three months 1 placebo capsule per day

DIETARY_SUPPLEMENT

Vitamin K1-capsules

27 participants received for 3 months 1 vitamin K1-capsule per day containing 52 µg of K1/day

DIETARY_SUPPLEMENT

Vitamin K2-capsules

27 participants received for 3 months 1 vitamin K2-capsule per day containing 75 µg of MK-7.

Sponsors & Collaborators

  • Maastricht University Medical Center

    lead OTHER

Principal Investigators

  • Cees Vermeer, PhD · VitaK BV Maastricht University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-03-31
Primary Completion
2011-06-30
Completion
2011-09-30

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01638182 on ClinicalTrials.gov