The MRC/ABPI COPD Cohort v1.7

Summary

The UK Medical Research Council (MRC) together with the Association of British Pharmaceutical Industries (ABPI) have recently funded a program designed to foster collaboration between academic COPD researchers and the pharmaceutical industry in the UK, with the aim of developing and furthering our research capacity and expertise for the benefit of patients living with this prevalent and disabling condition. This builds on the strong international track record of COPD research in the UK. The program is divided into four work packages (WP1-4), each with specific aims. WP1 will collate and establish data from patient cohorts and share this information through the development of knowledge management platforms. WP2 will specifically assess how airway micro-organisms impact on COPD and how the effects of bacteria and viruses may be modified. WP3 is concerned with tissue injury and repair which are fundamental processes in the development of COPD. WP4 will examine in detail the potential for improving patient outcomes by targeting the skeletal muscle dysfunction that can profoundly affect exercise capacity.

Conditions

• COPD

Interventions

RADIATION

CT scan and PA chest X-ray

All participants will receive a single high resolution CT scan of the chest. This will be performed using a low tube current, helical technique. Participants may also receive a plain chest X-ray if clinically indicated. The total research protocol dose is 2 mSv. The dose from the chest X-ray is insignificant compared with the dose from the CT scan of the chest, therefore all this dose can be considered to be additional to standard of care. A dose of 2 mSv represents a risk of radiation induced detriment of approximately 1 in 10,000 and is equivalent to about 11 months of average natural background radiation in the UK.

Sponsors & Collaborators

• Royal Free Hampstead NHS Trust

  collaborator OTHER

• Royal Brompton & Harefield NHS Foundation Trust

  collaborator OTHER

• Imperial College London

  collaborator OTHER

• Sheffield Teaching Hospitals NHS Foundation Trust

  collaborator OTHER

• University of Sheffield

  collaborator OTHER

• University Hospitals, Leicester

  collaborator OTHER

• University of Leicester

  collaborator OTHER

• University Hospital Birmingham NHS Foundation Trust

  collaborator OTHER

• University of Birmingham

  collaborator OTHER

• Cambridge University Hospitals NHS Foundation Trust

  collaborator OTHER

• University of Cambridge

  collaborator OTHER

• Liverpool University Hospitals NHS Foundation Trust

  collaborator OTHER_GOV

• University of Liverpool

  collaborator OTHER

• NHS Lothian

  collaborator OTHER_GOV

• University of Edinburgh

  collaborator OTHER

• Newcastle University

  collaborator OTHER

• University of Nottingham

  collaborator OTHER

• University of Southampton

  collaborator OTHER

• University College, London

  lead OTHER

Eligibility

Min Age

40 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-02-28

Countries

• United Kingdom

Study Locations