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Endothelial Dysfunction and Plaque Vulnerability

NCT01578616 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2015-08-07

No results posted yet for this study

Summary

Thinning of fibrous cap in atherosclerotic plaques is associated with plaque vulnerability. The high resolution of optical coherence tomography (OCT) provides an accurate measurement of fibrous cap thickness. Endothelial dysfunction is a key component of vulnerable plaque and digital reactive hyperemia-peripheral arterial tonometry (RH-PAT) is a non-invasive automatic and quantitative method to evaluate endothelial function. The investigators will investigate the association between endothelial function assessed by RH-PAT and plaque vulnerability determined by OCT-derived thin-cap fibroatheroma (TCFA).

Conditions

  • Acute Coronary Syndrome

Sponsors & Collaborators

  • Yokohama City University Medical Center

    lead OTHER

Principal Investigators

  • Kiyoshi Hibi, MD, PhD · Division of Cardiology, Yokohama City University Medical Center

Eligibility

Min Age
20 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-07-31
Primary Completion
2014-05-31
Completion
2014-05-31

Countries

  • Japan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01578616 on ClinicalTrials.gov