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Effects of Electroconvulsive Therapy (ECT) in Bipolar Depression

NCT01557933 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2012-11-29

No results posted yet for this study

Summary

The primary purpose of this study is to use magnetic resonance spectroscopy (MRS) to measure the levels of several brain chemicals including, but not limited to, glutamate, glutamine, and N-acetylaspartate, before and after treatment with ECT. In addition to MRS, the investigators will use several other MRI techniques including structural MRI, resting state functional MRI (fMRI), and diffusion tensor imaging (DTI) to measure how the structure and function of the brain changes with ECT.

The investigators hypothesize that the Gln/Glu ratio is increased in the anterior cingulate cortex (ACC), but not the parieto-occipital cortex (POC), following the first ECT treatment.

Conditions

Interventions

OTHER

No interventions will be used

No interventions will be used

Sponsors & Collaborators

  • Mclean Hospital

    lead OTHER

Principal Investigators

  • Brian P Brennan, M.D. · Mclean Hospital

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-04-30
Primary Completion
2012-07-31
Completion
2012-07-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01557933 on ClinicalTrials.gov