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Systemic Markers of Collagen Metabolism and Vitamin C in Smokers and Non-Smokers With Pelvic Organ Prolapse

NCT01548105 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 96

Last updated 2014-10-17

No results posted yet for this study

Summary

Data on smoking and POP are conflicting. In a study done by Alnaif et al, smoking was found to be associated with severe POP. The authors' proposed explanation was that smoking impairs tissue and wound healing. Our primary objective is to document whether smokers with pelvic organ prolapse (POP) are different from non-smokers with POP with respect to collagen biosynthesis and breakdown using systemic markers of collagen metabolism and Vitamin C.

Conditions

  • Pelvic Organ Prolapse

Interventions

OTHER

Blood draw for the study participants

These will include: * Procollagen 1-N propeptide levels (PINP) * Matrix metalloproteinase (MMP9) * Plasma Vitamin C levels

Sponsors & Collaborators

  • TriHealth Inc.

    lead OTHER

Principal Investigators

  • Maria Victoria C Estanol, MD · Good Samaritan Hospital

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-03-31
Primary Completion
2013-01-31
Completion
2013-03-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01548105 on ClinicalTrials.gov