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The Impact of Grapefruit Juice on the Response to Clopidogrel

NCT00817999 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2012-10-01

Study results available
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Summary

This study will measure the percentage of platelet aggregation inhibition with a loading dose of clopidogrel (300 mg) using the VerifyNow Assay System in healthy volunteers who have drank 11 oz of grapefruit juice. It will also measure the percentage of platelet aggregation inhibition with a maintenance dose of clopidogrel (75 mg/day) using the VerifyNow Assay System in healthy volunteers who have drank 11 oz grapefruit juice daily.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

Grapefruit juice

Participants received grapefruit juice during 1 of the 2 periods.

DRUG

Clopidogrel 75 mg/day

DRUG

Clopidogrel 300 mg

Sponsors & Collaborators

  • Creighton University

    lead OTHER

Principal Investigators

  • Tammy Burns, PharmD · Creighton Cardiac Center

Study Design

Allocation
RANDOMIZED
Purpose
SCREENING
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
19 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-11-30
Primary Completion
2011-07-31
Completion
2011-07-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00817999 on ClinicalTrials.gov