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Effect of Low-Dose Dexamethasone on the Incidence of Hyperglycemia Following Surgery

NCT01545700 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2019-09-30

Study results available
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Summary

The question of a possible hyperglycemic effect from single-dose dexamethasone is an important issue for clinicians managing patients in the intraoperative and postoperative periods. Recent evidence suggests that even moderate elevations in blood glucose levels may be associated with adverse events.

The aim of this clinical investigation is to determine whether standard clinical doses of dexamethasone produce hyperglycemia in the perioperative period.

Conditions

  • Postoperative Complications

Interventions

DRUG

Control-saline

Patients are randomized to receive saline 2 cc

DRUG

Dexamethasone 4 mg

Patients randomized to receive dexamethasone 4mg and 1 cc saline

DRUG

Dexamethasone 8 mg

Patients randomized to receive dexamethasone 8mg

DRUG

Control saline

Patients are randomized to receive saline 2 cc

DRUG

Dexamethasone 4 mg

Patients are randomized to receive dexamethasone 4 mg and saline 1 cc

DRUG

Dexamethasone 8 mg

Patients are randomized to receive dexamethasone 8 mg

Sponsors & Collaborators

  • Endeavor Health

    lead OTHER

Principal Investigators

  • Glenn S Murphy, MD · Endeavor Health

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-09-30
Primary Completion
2012-11-30
Completion
2012-11-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01545700 on ClinicalTrials.gov