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Glycemic Variability and Autonomic Nervous System in Cardiac Surgery Patients

NCT05454735 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2025-04-23

No results posted yet for this study

Summary

On-pump coronary artery bypass graft (CABG) and valve replacement surgeries are high-risk procedures. Among the risk factors for postoperative complications, perioperative hyperglycemia and blood glucose variability have been reported to be associated with increased morbidity and mortality. The treatment of hyperglycemia using intravenous insulin infusion improves the prognosis in cardiac surgery patients. However, the determinants of postoperative blood glucose variability and the mechanisms leading to its deleterious impact are unknown. Thus, to date, there is no therapeutic intervention that could effectively prevent and treat the deleterious impact of glycemic variability on postoperative outcome. The purpose of the study is to evaluate whether perioperative alteration of the autonomic nervous system and preoperative blood glucose variability could be related to perioperative glycemic variability.

Conditions

  • Blood Glucose Variability
  • Cardiac Surgical Procedures
  • Autonomic Nervous System

Interventions

PROCEDURE

coronary artery bypass surgery

coronary artery bypass surgery

PROCEDURE

aortic valve replacement surgery

aortic valve replacement surgery

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Besancon

    lead OTHER

Principal Investigators

  • Guillaume BESCH, MD, PhD · Centre Hospitalier Universitaire de Besançon

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-10-10
Primary Completion
2024-05-31
Completion
2024-06-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05454735 on ClinicalTrials.gov