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Norfloxacin Versus Ciprofloxacin for Spontaneous Bacterial Peritonitis (SBP) Prevention

NCT01542801 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 124

Last updated 2016-12-28

No results posted yet for this study

Summary

* For the prevention of spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis, norfloxacin 400mg per day is a standard regimen.
* Ciprofloxacin 750 mg per week is also known to be effective for prevention of SBP. In addition, ciprofloxacin once weekly administration is more convenient and less costly.
* Therefore ciprofloxacin once weekly could be more useful if the the efficacy is comparable to norfloxacin once daily.
* This study aims to prove ciprofloxacin once weekly administration is as effective as norfloxacin once daily administration for the prevention of SBP in cirrhotic patients with ascites.

Conditions

  • Adverse Reaction to Other Drugs and Medicines

Interventions

DRUG

Norfloxacin

Norfloxacin 400 mg per day

DRUG

ciprofloxacin

Ciprofloxacin 750 mg per week

Sponsors & Collaborators

  • Sungkyunkwan University

    collaborator OTHER

  • Kyungpook National University Hospital

    collaborator OTHER

  • Soon Chun Hyang University

    collaborator OTHER

  • Korea University

    lead OTHER

Principal Investigators

  • Soon Ho Um, M.D., Ph.D. · Korea University Anam Hospital

  • Hyung Joon Yim, M.D., Ph.D. · Korea University Ansan Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-08-31
Primary Completion
2015-07-31
Completion
2016-04-30

Countries

  • South Korea

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01542801 on ClinicalTrials.gov