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Platelet Derived Growth Factor Stimulates Bone Fill and Rate of Attachment Level Gain

NCT01530126 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 180

Last updated 2016-01-08

No results posted yet for this study

Summary

The aim of the study was to evaluate the safety and effectiveness of Platelet Derived Growth Factor (PDGF) mixed with b tricalcium phosphate (BTCP) for the treatment of advanced periodontal osseous defects at 6 months of healing.

Conditions

  • Periodontitis

Interventions

BIOLOGICAL

B-TCP + 0.3 mg/ml rhPDGF-BB in buffer

B-TCP mixed with sodium acetate buffer and 0.3 mg/ml rhPDGF-BB and placed into osseous defect once at baseline visit.

BIOLOGICAL

B-TCP + 1.0 mg/ml rhPDGF-BB in buffer

B-TCP mixed with sodium acetate buffer and 1.0 mg/ml rhPDGF-BB and placed into osseous defect once at baseline visit.

BIOLOGICAL

B-TCP +buffer

B-TCP mixed with sodium acetate buffer and placed into osseous defect once at baseline visit.

Sponsors & Collaborators

Principal Investigators

  • William Giannobile, DDS, DMedSc · University of Michigan

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2000-01-31
Primary Completion
2005-01-31
Completion
2007-01-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01530126 on ClinicalTrials.gov