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Effect of Concentrated Growth Factors on Healing of Apicomarginal Defects: a Prospective Study

NCT05938907 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 72

Last updated 2023-09-21

No results posted yet for this study

Summary

The persistent and chronic apical periodontitis has caused great difficulties for clinical physicians. Ensuring rapid and successful healing of the extensively damaged periapical region is a pressing issue that needs to be addressed. The treatment options include traditional apical surgery, simultaneous placement of bone powder and membrane after apical surgery, and simultaneous placement of sticky bone (bone powder mixed with concentrated growth factors gel) and membrane. However, high-quality evidence regarding these various treatment options is scarce. The purpose of this study is to compare the advantages and disadvantages of each treatment option, in order to guide clinical physicians in the application of apical surgery.

Conditions

  • Concentrated Growth Factor
  • Bone Substitute

Interventions

OTHER

concentrated growth factor

Implanting concentrated growth factor into the area of root apical bone defect

OTHER

bone substitute

Implanting bone substitute into the area of root apical bone defect

COMBINATION_PRODUCT

concentrated growth factor + bone substitute

Implanting concentrated growth factor + bone substitute into the area of root apical bone defect

Sponsors & Collaborators

  • West China Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-06-15
Primary Completion
2024-12-31
Completion
2024-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05938907 on ClinicalTrials.gov