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Metformin for the Treatment of Unexplained Oligozspermia

NCT01529177 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 600

Last updated 2015-08-07

No results posted yet for this study

Summary

Insulin resistance (IR) in men may be the underlying pathogenesis for metabolic abnormalities and chronic hypospermatogenesis similar to women with polycystic ovarian disease (PCOD). Infertile men with unexplained infertility and IR may benefit from treatment with metformin.

Conditions

Interventions

DRUG

Metformin / clomid / hCG

Metformin 1000 mg daily for a week then twice daily for 2 weeks then 3 tomes daily for 6 months.

DRUG

Clomiphene citrate / hCG

Clomiphene citrate 50 mg daily for one month, then twice daily for 2 months then 3 times per day for 3 months.

Sponsors & Collaborators

  • The Egyptian IVF-ET Center

    lead OTHER

Principal Investigators

  • Ragaa mansour, MD,PhD · The Egyptian IVF-ET Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
50 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-02-29
Primary Completion
2016-09-30
Completion
2017-02-28

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01529177 on ClinicalTrials.gov