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Gene Expression, Immunological Status and Metabolome in Glioma Patients

NCT01525459 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 16

Last updated 2012-02-07

No results posted yet for this study

Summary

Study on glioma patients treated with brain surgery is focusing on the analysis of their transcriptome expression profile measured in two immune cell populations, CD4+ T cells and CD56+ NK cells. The results of analysis will be compared to the reference data of healthy population. Furthermore, the metabolomic and immunological status will also be monitored and compared to healthy group reference data, before and after the surgery\*. With comparative crossomics analysis the investigators intend to possibly identify new diagnostic and prognostic biological markers for the relapse of the disease. The results are expected to convey a deeper insight into pathophysiology of the glioma as well as into the mechanisms of the current surgical therapy.

\* The healthy reference data have been published in collaborative efforts of BTC, UMC and NIB (Gruden et al. 2012).

Conditions

Interventions

PROCEDURE

Glioma resection

Patients will be treated with the standard surgical therapy - glioma resection.

OTHER

Blood sampling

Blood samples used for measuring studied parameters will be taken within 10 days before surgery, one day after surgery and once more within 10 days following the operative procedure.

Sponsors & Collaborators

  • Blood Transfusion Centre of Slovenia

    collaborator OTHER_GOV

  • University Medical Centre Ljubljana

    collaborator OTHER

  • National Institute of Biology, Slovenia

    lead OTHER_GOV

Principal Investigators

  • Tamara Lah Turnšek, PhD · National Institute of Biology, Ljubljana, Slovenia

  • Kristina Gruden, PhD · National Institute of Biology, Ljubljana, Slovenia

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-12-31
Primary Completion
2012-08-31
Completion
2012-12-31

Countries

  • Slovenia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01525459 on ClinicalTrials.gov