Multicenter Perioperative Opioid Pharmacogenetic Study

Summary

The purpose of this research study is to identify factors and genes (the DNA material that determines the makeup of the human body) that may be associated with how children respond to pain medication. Specifically, the investigators want to study factors that may be associated with pain sensitivity, morphine requirement after surgery and side-effects from morphine and other pain medications. The investigators expect that the information obtained in this research study will help us to develop more effective, safe, and tailored treatment options in the future.

Conditions

• Pain

Sponsors & Collaborators

• Baylor College of Medicine

  collaborator OTHER

• Ochsner Health System

  collaborator OTHER

• Children's Hospital Colorado

  collaborator OTHER

• Children's Hospital Los Angeles

  collaborator OTHER

• C.S. Mott Children's Hospital

  collaborator OTHER

• St. Christopher's Hospital for Children

  collaborator OTHER

• St. Louis Children's Hospital

  collaborator OTHER

• Boston Children's Hospital

  collaborator OTHER

• Seattle Children's Hospital

  collaborator OTHER

• Ann & Robert H Lurie Children's Hospital of Chicago

  collaborator OTHER

• University of Wisconsin, Madison

  collaborator OTHER

• University of Miami

  collaborator OTHER

• Johns Hopkins University

  collaborator OTHER

• Stanford University

  collaborator OTHER

• Phoenix Children's Hospital

  collaborator OTHER

• University of Michigan

  collaborator OTHER

• University of Utah

  collaborator OTHER

• Shanghai Children's Hospital

  collaborator OTHER

• Children's Hospital Medical Center, Cincinnati

  lead OTHER

Principal Investigators

• Senthilkumar Sadhasivam · Children's Hospital Medical Center, Cincinnati

Eligibility

Min Age

6 Years

Max Age

17 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-11-30

Primary Completion

2016-01-31

Completion

2017-04-30

Countries

• United States

Study Locations