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The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory

NCT01494623 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 122

Last updated 2013-06-11

No results posted yet for this study

Summary

Deficits in working memory (WM) performance are the most significant cognitive impairments in schizophrenia (SCZ). It has also been shown that WM performance is contingent on the cortex synchronization, a process that relies on brain inhibition. Repetitive Transcranial Magnetic Stimulation (rTMS) has been demonstrated as an effective treatment for patients with SCZ and has been shown to increase brain inhibition and improve cognitive performance. In this study the investigators intend to:

* evaluate rTMS as a treatment for WM deficits in SCZ
* evaluate rTMS as a method to increase WM performance in healthy individuals
* determine if improvements in WM performance are related to enhanced synchronization of brain networks
* determine whether genetic polymorphisms predict cortical function and treatment response
* evaluate the influence of rTMS treatment on brain structure.

Conditions

Interventions

DEVICE

repetitive Transcranial Magnetic Stimulation

Magnetic pulses to specified brain regions.

Sponsors & Collaborators

  • Centre for Addiction and Mental Health

    lead OTHER

Principal Investigators

  • Z. Jeff Daskalakis, MD, PhD · CAMH

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-05-31
Primary Completion
2012-11-30
Completion
2012-11-30

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01494623 on ClinicalTrials.gov