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Effect of Repetitive Transcranial Magnetic Stimulation on Resting State Brain Activity in Schizophrenia

NCT01620086 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 26

Last updated 2016-10-31

Study results available
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Summary

This study compares the efficacy of low and high frequency repetitive transcranial magnetic stimulation (rTMS) as a means of treating subjects with schizophrenia. Magnetic pulses delivered over the scalp cause brain activity. This activity has been shown to help decrease the intensity and frequency of auditory hallucinations (AH) in schizophrenia. The investigators will compare whether low or high frequencies work best. The investigators will also examine what changes occur in the brain that are related to improvement.

Conditions

Interventions

DEVICE

Active Repetitive Transcranial Magnetic Stimulation 1 Hz

active rTMS delivered at 1Hz frequency over temporal cortex

DEVICE

Active Repetitive Transcranial Magnetic Stimulation 10 Hz

active rTMS delivered at 10 Hz frequency over temporal cortex

DEVICE

Active control site Repetitive Transcranial Magnetic Stimulation at 1Hz

active rTMS delivered at either 1 Hz frequency over the vertex

DEVICE

Sham control site Repetitive Transcranial Magnetic Stimulation

sham rTMS delivered at 1Hz frequency over the vertex

DEVICE

Active control site Repetitive Transcranial Magnetic Stimulation at 10 Hz

Active 10 Hz rTMS delivered over the vertex

Sponsors & Collaborators

  • University of Arkansas

    lead OTHER

Principal Investigators

  • Erick Messias, MD, MPH, PhD · University of Arkansas

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-06-30
Primary Completion
2015-08-31
Completion
2015-08-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01620086 on ClinicalTrials.gov