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rTMS Add on Value for Amelioration of Negative Symptoms of Schizophrenia

NCT04318977 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 62

Last updated 2025-09-19

No results posted yet for this study

Summary

Treatment of depression with repetitive transcranial magnetic stimulation (rTMS) has shown high evidence using high-frequency left dorsolateral prefrontal cortex (DLPFC) stimulation. The treatment of negative symptoms with the same protocol in schizophrenia is considered as possible effective. Theta burst stimulation is a new protocol which is characterized by shorter sessions showing first evidence that it's efficacy is comparable to the high-frequency rTMS. In this randomized placebo-controlled study the efficacy of high-frequency rTMS and TBS are evaluated.

Conditions

  • Negative Symptoms With Primary Psychotic Disorder
  • Schizophrenia

Interventions

DEVICE

high-frequency rTMS

repetitive transcranial magnetic stimulation

DEVICE

TBS

theta burst stimulation

DEVICE

placebo

placebo transcranial magnetic stimulation

Sponsors & Collaborators

  • University Hospital, Aachen

    collaborator OTHER

  • University Hospital Ostrava

    collaborator OTHER

  • Brno University Hospital

    collaborator OTHER

  • University of Regensburg

    lead OTHER

Principal Investigators

  • Berthold Langguth, MD, PhD · University of Regensburg

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-02-01
Primary Completion
2024-08-14
Completion
2025-12-30

Countries

  • Czechia
  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04318977 on ClinicalTrials.gov