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Central Nervous Processing of Visual Food Stimuli in Severely Obese Subjects

NCT01493583 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 38

Last updated 2025-03-12

No results posted yet for this study

Summary

Recent evidence has pointed to distinct alterations of brain functions in obese subjects some of which may even be causative for their obesity. The objective of this study was to examine food and non food related alterations in brain functions after excessive weight loss due to Roux-en Y gastric bypass surgery (RYGB), one of the most successful therapeutic approaches for long lasting weight loss. The investigators hypothesized that obese as compared with lean women show an altered activation pattern in the brain areas involved in the homeostatic regulation of eating behavior, i.e. the hypothalamus, in reward-related brain areas, such as the orbital frontal cortex (OFC) and the striatum as well as in prefrontal inhibitory control areas. Furthermore, the investigators hypothesized that women who had undergone a RYGB operation show a brain activity pattern that more closely mimics that of lean than severely obese women. In a supplementary test the investigators will assess gastrointestinal and metabolic response to a standardized meal in order to elucidate putative correlation of these responses with the results of fMRI scannings.

Conditions

Sponsors & Collaborators

  • German Federal Ministry of Education and Research

    collaborator OTHER_GOV

  • Competence Network for Adiposity funded by the German Federal Ministry of Education and Research (FKZ: 01GI0837) and (FKZ: 01GI0849)

    collaborator UNKNOWN

  • Cantonal Hospital of St. Gallen

    lead OTHER

Principal Investigators

  • Bernd Schultes, Prof. Dr. med. · Interdisciplinary Obesity Center, Kantonal Hospital St. Gallen, Rorschach, Switzerland

  • Niels Birbaumer, Prof. Dr. · Institute of Medical Psychology and Behavioural Neurobiology, University of Tübingen, Tübingen, Germany

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-09-30
Primary Completion
2012-12-31
Completion
2012-12-31

Countries

  • Switzerland

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01493583 on ClinicalTrials.gov