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Gatifloxacin Versus Ceftriaxone in the Treatment of Enteric Fever

NCT01421693 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 300

Last updated 2016-10-04

No results posted yet for this study

Summary

The investigators aim to compare two antibiotic treatments for enteric (typhoid) fever. Three hundred patients at Patan Hospital will be enrolled in the study. Patients will be assigned to one of the two treatments by chance and followed for 6 months. The two treatment groups will be compared to see which treatment is more likely to make the patient better.

Conditions

  • Enteric Fever
  • Typhoid Fever

Interventions

DRUG

Ceftriaxone

* ≥2-\<14 years - 60mg/kg/ once daily for 7 days * 14 years and older - 2g once daily for 7 days * Intravenous infusion. Vials of crystalline powder.

DRUG

Gatifloxacin

Gatifloxacin 10 mg/kg/day for 7 days. Tablets for oral administration.

Sponsors & Collaborators

  • University of Oxford

    collaborator OTHER

  • Patan Academy of Health Sciences, Nepal

    collaborator UNKNOWN

  • Patan Hospital, Nepal

    collaborator UNKNOWN

  • Civil Hospital, Nepal

    collaborator UNKNOWN

  • Oxford University Clinical Research Unit, Vietnam

    lead OTHER

Principal Investigators

  • Buddha Basnyat, MD · University of Oxford

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
2 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-09-30
Primary Completion
2014-07-31
Completion
2015-01-31

Countries

  • Nepal

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01421693 on ClinicalTrials.gov