Ceftriaxone is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections including pneumonia, meningitis, urinary tract infections, gonorrhea, and sepsis. It is administered intravenously or intramuscularly. It is a widely used prescription antibacterial medicine.
A 19-month-old girl with influenza A (H1N1)-associated acute necrotizing encephalitis made a complete neurological recovery despite a severity score of 6. Multimodal immunomodulatory therapy including IVIG, corticosteroids, anakinra, and plasma exchange led to rapid decline in blood cytokine levels. The case underscores early recognition and targeted treatment in young children.
The U.S. FDA approved Nuzolvence (zoliflodacin), a single-dose oral treatment for uncomplicated urogenital gonorrhea, based on a non-inferiority Phase 3 trial. Thailand also authorized the drug under the brand Nuzolvance, expanding access in low- and middle-income countries.
The CDC is investigating a multistate outbreak of extensively drug-resistant Salmonella Newport with an NDM-1 gene linked to Rosabella moringa powder capsules, marking the first documented outbreak of Salmonella with an NDM-1 gene in the United States.
CDC and FDA are investigating a multistate outbreak of extensively drug-resistant Salmonella Newport infections linked to Rosabella brand moringa powder capsules, with seven people sickened across seven states and three requiring hospitalization.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT06828952 |
Risk Factors of Failure of Conservative Treatment in Acute Non Complicated Appendicitis |
NOT_YET_RECRUITING | |
| NCT06349122 |
AUTOP 2: Screen-and-treat Strategy for Vaginal Flora Abnormalities by Molecular Biology in Pregnant Women at High Risk of Preterm Birth |
NOT_YET_RECRUITING | PHASE3 |
| NCT05980871 |
Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline |
TERMINATED | PHASE4 |
| NCT05971550 |
Clearance of Asymptomatic Pharyngeal Carriage of Neisseria Gonorrhoeae With or Without Ceftriaxone Treatment: Randomized Non-inferiority Study |
NOT_YET_RECRUITING | PHASE3 |
| NCT05470517 |
Antibiotic Instillation in Appendicitis |
COMPLETED | PHASE2 |
| NCT05375240 |
Propranolol on Post Stroke Immune Status and Infection |
UNKNOWN | PHASE2 |
| NCT05294588 |
Efficacy of Immunization With 4C-MenB in Preventing Experimental Urethral Infection With Neisseria Gonorrhoeae |
COMPLETED | PHASE2 |
| NCT05149287 |
PROPER Trial of Pain and Inflammation After Knee Arthroscopy |
TERMINATED | PHASE2 |
| NCT05079620 |
Early Antibiotics After Aspiration in ICU Patients |
TERMINATED | PHASE4 |
| NCT04870138 |
Experimental Human Infection With Neisseria Gonorrhoeae (LptA Trial) |
COMPLETED | PHASE1 |
