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Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery

NCT01418118 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2011-08-16

No results posted yet for this study

Summary

Following surgery to remove tumours of the head and neck, patients undergo reconstruction with free flaps - tissue that is taken from elsewhere in the body and given a new blood supply by attaching it to vessels in the neck. Following this type of surgery, patients often need medication to maintain their blood pressure in the intensive care unit. The effect of these drugs on the transplanted tissues is unknown. This study investigates the effects of four commonly used drugs on free flap perfusion.

Conditions

Interventions

DRUG

Epinephrine

0.2mcg/kg/min maximum infusion; to increase mean arterial pressure by 30mmHg

DRUG

Norepinephrine

Maximum infusion of 0.2mcg/kg/min, to increase mean arterial pressure by 30mmHg

DRUG

Dobutamine

Maximum infusion rate of 8mcg/kg/min to increase mean arterial pressure by 30mmHg

DRUG

Dopexamine

Maximum infusion rate of 5mcg/kg/min to increase mean arterial pressure by 30mmHg

Sponsors & Collaborators

  • Oxford University Hospitals NHS Trust

    lead OTHER

Principal Investigators

  • Stephen R Watt-Smith, FDSRCS, MD · Oxford University Hospitals NHS Trust

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
17 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-10-31
Primary Completion
2010-02-28
Completion
2010-02-28

Countries

  • United Kingdom

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01418118 on ClinicalTrials.gov