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Analysis of Toxins in Follicle Fluid

NCT01385605 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 210

Last updated 2021-03-08

No results posted yet for this study

Summary

Environmental pollutants might be jointly responsible for increase of infertility among women. Especially endocrin active substances seem to be of particular importance. These substances are chemicals which interfere with the physiological system of humans and animals. They have a negative impact on the endocrine system and disturb the functions of organs whose hormones regulate the male and female reproductive system.

It is known that exposition to these chemicals lead to subfertility, infertility, raised abortions, birth defects and ovarian malfunction.

Additionally it was shown that human embryos have a decreased cleavage rate after IVF when developing from oocytes with elevated concentrations of environmental pollutants.

In this study the main focus concentrates on Nonylphenols (NP). Follicular fluids of women with subfertility will be analyzed by a newly developed principle including HPLC and NMR-Spectroscopy. This enables quantitative and qualitative analysis of enantiomers of NP.

The results will allow risk estimations for several endocrine active substances, especially NP.

Additionally conclusions concerning the correlation between thes substances and subfertility can be drawn.

Conditions

  • Environmental Exposure to Harmful Algae and Toxins
  • Female Subfertility

Sponsors & Collaborators

  • TU Dortmund University

    collaborator UNKNOWN

  • Ferring Pharmaceuticals

    collaborator INDUSTRY

  • Infertility Treatment Center Dortmund

    lead OTHER

Principal Investigators

  • Stefan Dieterle · Infertility Treatment Center Dortmund

Eligibility

Min Age
18 Years
Max Age
39 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-08-31
Primary Completion
2020-06-30
Completion
2021-02-23

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01385605 on ClinicalTrials.gov