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Racial Disparity in Barrett's Esophagus

NCT01374074 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 255

Last updated 2015-09-23

No results posted yet for this study

Summary

The goal of the proposed research is to investigate the molecular mechanisms of racial disparity in Barrett's esophagus (BE), the premalignant lesion of esophageal adenocarcinoma. Specifically, the investigators hypothesize that environmental factors, genetic factors, and potentially gene environment interactions play crucial roles in the observed racial disparity in developing Barrett's esophagus.

Patients are recruited through UNC hospitals prior to scheduled esophagogastroduodenoscopy (EGD). Participants complete a questionnaire, have body measurements obtained, and have blood, biopsies, and gastric aspirate collected. Participants also complete a 24 hour pH impedance test.

Conditions

  • Barrett's Esophagus
  • Gastroesophageal Reflux Disease (GERD)
  • Intestinal Metaplasia

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • University of North Carolina, Chapel Hill

    lead OTHER

Principal Investigators

  • Nicholas Shaheen, MD, MPH · University of North Carolina, Chapel Hill

  • Xiaoxin Chen, MD, PhD · North Carolina Central University

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-03-31
Primary Completion
2014-01-31
Completion
2014-01-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01374074 on ClinicalTrials.gov