High-dose Dexamethasone Versus Conventional Dose Prednisone for Initial Treatment of Primary Immune Thrombocytopenia (ITP)

Summary

The project was undertaking by Qilu Hospital of Shandong University and other 11 well-known hospitals in China. In order to report the efficacy and safety of high-dose dexamethasone compared to conventional dose prednisone for the first-line treatment of adults with primary immune thrombocytopenia(ITP).

Conditions

• Purpura, Thrombocytopenic, Idiopathic

Interventions

DRUG

Prednisone

Prednisone, po, 1 mg/kg/d, for 4 weeks.

DRUG

Dexamethasone

Dexamethasone, po, 40 mg/d, for 4 days.

Sponsors & Collaborators

• Chinese Academy of Medical Sciences

  collaborator OTHER

• Peking Union Medical College Hospital

  collaborator OTHER

• Ruijin Hospital

  collaborator OTHER

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

  collaborator OTHER

• Tongji Hospital

  collaborator OTHER

• Shandong University of Traditional Chinese Medicine

  collaborator OTHER

• Anhui Provincial Hospital

  collaborator OTHER_GOV

• Zhejiang Provincial Hospital of TCM

  collaborator OTHER

• Second Hospital of Shanxi Medical University

  collaborator OTHER

• People's Hospital of Xinjiang Uygur Autonomous Region

  collaborator OTHER

• Shenzhen Second People's Hospital

  collaborator OTHER

• Shandong University

  lead OTHER

Principal Investigators

• Ming Hou, DR. · Shandong University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2010-09-30

Primary Completion

2014-05-31

Completion

2015-03-31

Countries

• China

Study Locations