MedTrace Logo

TENS Effectiveness and Knee Osteoarthritis in Humans

NCT01354054 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2011-05-16

No results posted yet for this study

Summary

TENS is a non pharmacological intervention to control pain. Both high (\>50 Hz) and low (\<10 Hz) frequency TENS are used in the clinic and it is thought that each type works through different mechanisms (see for review Sluka and Walsh, 2003). Hyperalgesia, an increased response to a noxious stimuli, is one component of pain and occurs both at the site of injury, primary hyperalgesia, and outside the site of injury, secondary hyperalgesia. Recent studies in animals with arthritis of the knee show that low and high frequency TENS differentially modulate primary and secondary hyperalgesia.

Therefore the investigators hypothesize that TENS will reduce hyperalgesia and pain with movement resulting in increased function.

Conditions

Interventions

PROCEDURE

High Frequency TENS

100 usec, 100 Hz, pulse amplitude motor - 10%, 30-40 minutes

PROCEDURE

Low frequency TENS

100 usec, 4 Hz, pulse amplitude motor - 10%, 30-40 minutes

PROCEDURE

Placebo TENS

100 usec, 100 Hz, motor - 10%, pulse amplitude adjusted and maintained for 30 seconds then ramping down to zero in 15 seconds

Sponsors & Collaborators

  • University of Iowa

    lead OTHER

Principal Investigators

  • Barbarb A Rakel, PhD · University of Iowa College of Nursing

  • Kathleen A Sluka, PhD · University of Iowa Physical Therapy and Rehabilitation Science Graduate Program

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
95 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-11-30
Primary Completion
2009-06-30
Completion
2009-06-30

Countries

  • United States
  • Brazil
  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01354054 on ClinicalTrials.gov