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Asymptomatic Bacteriuria & Risk of Urinary Tract Infection in Renal Transplants

NCT01349738 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2011-09-01

No results posted yet for this study

Summary

The goal of this research program is to understand the natural history of asymptomatic bacteriuria in the renal transplant patients, to determine if screening for asymptomatic bacteriuria and identification of key host characteristics and virulence factors present on uropathogenic bacteria identifies a sub-population of patients with asymptomatic bacteriuria that are at risk to develop symptomatic urinary tract infection. Ultimately, the knowledge obtained from this study will prevent inappropriate antibiotic use and may identify whether certain bacterial isolates predispose to renal allograft injury. We will test the hypothesis that (i) asymptomatic bacteriuria is common in the renal allograft recipient and (ii) that symptomatic urinary tract infection and renal allograft dysfunction do not occur unless key host susceptibility factors and uropathogenic bacterial virulence factors are present.

Conditions

Interventions

DRUG

Antibiotic

Antibiotic (drug) sensitive to most recent culture for these subjects testing ASB positive and also experience Signs and symptoms of a UTI

Sponsors & Collaborators

  • University of Alabama at Birmingham

    collaborator OTHER

  • Rice, James C., M.D.

    lead OTHER

Principal Investigators

  • James C. Rice, MD · Scripps

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-05-31
Completion
2013-05-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01349738 on ClinicalTrials.gov