COMPERA / COMPERA-KIDS

Summary

In view of the manifold options for mono- and combination therapy that have now emerged for patients with pulmonary (arterial) hypertension (PH/PAH), controlled clinical trials can only provide part of the information needed for optimal management. In order to gather adequate data on PAH/PH treatment in routine clinical care, the ongoing COMPERA registry prospectively documents consecutive patients with newly initiated treatment of PAH/PAH since May 2007. The internet-based registry fulfills high quality standards through several measures (planned minimum centre contribution of at least 10 patients per year, automated plausibility checks of data at entry, queries, monitoring with source data verification in \>50% of participating centers). It can be applied, among further purposes, for quality assurance: individual centers can confidentially compare their results with the combined outcome of other centers and the recommendations from guidelines. It is expected that the register contributes to optimization of specific drug therapy for PAH and PH.

Since July 2013, also children of any age can be documented (COMPERA-KIDS).

Conditions

• Pulmonary Arterial Hypertension (PAH)
• Pulmonary Hypertension (PH)

Sponsors & Collaborators

• GWT-TUD GmbH

  collaborator OTHER

• Technische Universität Dresden

  lead OTHER

Principal Investigators

• Marius M Hoeper, MD, PhD · Department of Pulmonology, Medical School Hannover, Germany

• Ardeschir H. Ghofrani, MD, PhD · Lung Centre, Giessen, Germany

• Marion Delcroix, MD, PhD · Dept of Pneumology, University Leuven, Belgium

• Dario Vizza, MD, PhD · Department of Cardiovascular and Respiratory Sciences, University La Sapienza, Rome, Italy

• David Pittrow, MD, PhD · Institute for Clinical Pharmacoloy, Medical Faculty, Technical University Dresden, Germany

• Christian Opitz, MD, PhD · Department of Cardiology, DRK-Kliniken Berlin, Germany

• Oliver Distler, MD, PhD · Department for Rheumatology, University Hospital Zurich, Switzerland

• Harald Kaemmerer, MD, PhD · German Heart Centre, Munich, Germany

• Stephan Rosenkranz, MD, PhD · Heart Centre, Cologne

• Ekkehard Grünig, MD, PhD · Centre for Pulmonary Hypertension at Thoraxclinic Heidelberg, Germany

• Matthias Gorenflo, MD, PhD · Dept. Paed. Cardiol./Congenital Cardiology, Heidelberg University Medical Centre, Germany

• Karen Olsson, MD, PhD · Department of Pulmonology, Medical School Hannove

Eligibility

Min Age

1 Week

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2007-07-01

Primary Completion

2026-12-31

Completion

2026-12-31

Countries

• Belgium
• Germany
• Italy
• Switzerland

Study Locations