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Genetic Determinants of Cardiovascular Response to Coffee Drinking

NCT01330680 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 110

Last updated 2011-04-07

No results posted yet for this study

Summary

Cardiovascular and neuropsychologic effects of coffee are still debated. The precise mechanism underlying the actions of caffeine on the cardiovascular and neuropsychologic systems is incompletely understood and a considerable variability in the response to coffee drinking was observed, in part ascribable to a genetic trait.

The aim of the study is to evaluate acute cardiovascular and neuropsychologic effects of coffee and explore whether such effects are influenced by the genetic asset of caffeine metabolism (by a polymorphisms of cytochrome P450 1A2), adenosine metabolism (by polymorphisms of adenosine receptor and adenosine monophosphate deaminase) or catecholamine receptors (by polymorphisms of adrenergic receptors).

Conditions

  • Caffeine

Interventions

DIETARY_SUPPLEMENT

Decaffeinated coffee

40 mL dose of decaffeinated coffee

DIETARY_SUPPLEMENT

Coffee

40 mL dose of a decaffeinated preparation spiked with the addition of caffeine, at a dose of 3 mg/kg

Sponsors & Collaborators

  • Institute for Scientific Information on Coffee

    collaborator OTHER

  • Italian Istituto Nazionale Ricerche Cardiovascolari

    collaborator UNKNOWN

  • G. d'Annunzio University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-09-30
Primary Completion
2006-12-31
Completion
2010-09-30

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01330680 on ClinicalTrials.gov