National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions

Summary

The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). GenTAC established a registry of 3706 patients with genetic conditions that may be related to thoracic aortic aneurysms and collected medical data and biologic samples. The study ended in September 2016. Data and samples are available from NHLBI and requests should be made to BioLINCC. See the NHLBI website for more information: https://www.nhlbi.nih.gov/research/resources/gentac/.

Conditions

• Marfan Syndrome
• Turner Syndrome
• Ehlers-Danlos Syndrome
• Loeys-Dietz Syndrome
• FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 Genetic Mutation
• Bicuspid Aortic Valve Without Known Family History
• Bicuspid Aortic Valve With Family History
• Bicuspid Aortic Valve With Coarctation
• Familial Thoracic Aortic Aneurysm and Dissections
• Shprintzen-Goldberg Syndrome
• Other Aneur/Diss of Thoracic Aorta Not Due to Trauma, <50yo
• Other Congenital Heart Disease

Sponsors & Collaborators

• National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

  collaborator NIH

• National Heart, Lung, and Blood Institute (NHLBI)

  lead NIH

Principal Investigators

• Barbara Kroner, PhD, MPH · RTI International

• Richard Devereux, MD · The New York Presbyterian Hospital-Weill Cornell Medical Center

• William Ravekes, M.D. · Johns Hopkins University

• Reed E. Pyeritz, M.D., Ph.D. · University of Pennsylvania

• Dianna M. Milewicz, M.D. Ph.D. · University of Texas Medical School at Houston

• Scott A. LeMaire, M.D. · Baylor College of Medicine

• Cheryl L. Maslen, Ph.D. · Oregon Health and Science University

• Ralph Shohet, MD · University of Hawaii

• Jennifer Habashi, MD · Johns Hopkins University

• Federico M. Asch, MD,FACC,FASE · MedStar Health

• Kim Eagle, M.D. · University of Michigan

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2007-11-30

Primary Completion

2015-09-30

Completion

2016-09-30

Countries

• United States

Study Locations