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Closed-loop Control of Glucose Levels in the Context of Exercise in Adults With Type-1 Diabetes

NCT01297946 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2012-04-23

No results posted yet for this study

Summary

Recent developments of continuous glucose sensors and insulin infusion pumps have motivated the research toward closed-loop strategies to regulate glucose levels in patients with type 1 diabetes. In a closed-loop strategy, the pump(s) infusion rate is altered based on a computer-generated recommendation that relies on continuous glucose sensor readings. In this study, we aim to compare the effectiveness of dual-hormone (insulin+glucagon) closed-loop strategy to open-loop conventional continuous subcutaneous insulin infusion pump (CSII) therapy in regulating glucose levels during an evening exercise and on a night following an exercise in adults with type 1 diabetes.

Conditions

Interventions

DEVICE

Conventional continuous subcutaneous insulin infusion therapy

DEVICE

Dual-hormone closed-loop

Sponsors & Collaborators

  • McGill University

    collaborator OTHER

  • Montreal Children's Hospital of the MUHC

    collaborator OTHER

  • Diabetes Québec

    collaborator OTHER

  • Medtronic Minimed

    collaborator UNKNOWN

  • Institut de Recherches Cliniques de Montreal

    lead OTHER

Principal Investigators

  • Rémi Rabasa-Lhoret, M.D., Ph.D. · Institut de Recherches Cliniques de Montréal (IRCM)

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Countries

  • Canada

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01297946 on ClinicalTrials.gov