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MAPP Investigation of Pelvic Floor-Brain Neurobiologic Axis in IC/IBS and IBS

NCT01280864 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 36

Last updated 2018-07-23

No results posted yet for this study

Summary

Hypotheses:

1. The bidirectional signaling between the cortex, and the pelvic floor/gut is deranged in patients with IC and in IBS. Consequently, they will demonstrate hyperexcitability of the pelvic floor/brain axis as evidenced by shorter latencies and increased amplitudes for both the afferent anorectal-cortical evoked potentials and efferent cortically-induced (magnetic) anorectal motor evoked potentials.
2. Unlike patients with IC alone, patients with IBS will also demonstrate anorectal visceral hypersensitivity and anorectal sensory-motor dysfunction.

Conditions

  • Interstitial Cystitis
  • Irritable Bowel Syndrome

Sponsors & Collaborators

  • Augusta University

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-03-31
Primary Completion
2011-08-31
Completion
2011-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01280864 on ClinicalTrials.gov