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Mechanisms of Mitochondrial Defects in Gulf War Syndrome

NCT01264471 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 26

Last updated 2015-04-13

No results posted yet for this study

Summary

The purpose of the study is to investigate possible causes for Gulf War Syndrome. Gulf War Syndrome is associated with increased incidences of amyotrophic lateral sclerosis (Lou Gehrig's Disease), pain syndromes, muscle complaints that include fatigue and myalgias (muscle pain), as well as other neurological symptoms. Abnormalities in the part of the cell known as mitochondria have been delineated in Gulf War Syndrome. Mitochondria are the "power plants" of the body. Mitochondria take the food you eat and break the food down into a form of energy that the body can use. The investigators propose that Gulf War Syndrome is determined by a complex interaction of factors that interfere with mitochondrial function. This study will be the first investigation of mitochondrial function in Gulf War Syndrome. The investigators objective is to establish the cause for symptoms in affected veterans, develop testing that can more easily identify Gulf War Syndrome, and ultimately develop treatment protocols for Gulf War Syndrome.

Conditions

Interventions

PROCEDURE

Skin biopsy

A small skin sample will be obtained from the patients arm which is approximately the size of the top of a thumbtack (a small circle no more than a 1/4 inch across)

PROCEDURE

Blood Collection

Approximately 45ml or 3 tablespoons for blood will be drawn from a vein in the patient's forearm.

Sponsors & Collaborators

  • United States Department of Defense

    collaborator FED

  • Medical Neurogenetics, LLC

    lead OTHER

Principal Investigators

  • John M Shoffner, MD · Medical Neurogenetics

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-05-31
Primary Completion
2013-06-30
Completion
2013-06-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01264471 on ClinicalTrials.gov