MedTrace Logo

Mitochondrial Dysfunctions Driving Insulin Resistance

NCT06080581 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2025-06-22

No results posted yet for this study

Summary

The overarching aim of this observational study is to characterize muscle mitochondrial defects in individuals harboring pathogenic mitochondrial DNA (mtDNA) mutations associated with an insulin-resistant phenotype.

In a case-control design, individuals with pathogenic mtDNA mutations will be compared to controls matched for sex, age, and physical activity level. Participants will attend a screening visit and two experimental trials including:

* An oral glucose tolerance test
* A hyperinsulinemic-euglycemic clamp combined with measurements of femoral artery blood flow and arteriovenous difference of glucose
* Muscle biopsy samples

Conditions

  • Mitochondrial Myopathies
  • Mitochondrial Diseases
  • Mitochondrial Disorders

Sponsors & Collaborators

  • University of Copenhagen

    collaborator OTHER

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Matteo Fiorenza, Ph.D. · Rigshospitalet, Denmark

  • John Vissing, MD · Rigshospitalet, Denmark

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-20
Primary Completion
2024-12-20
Completion
2024-12-20

Countries

  • Denmark

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06080581 on ClinicalTrials.gov