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Lithia Water Study: Effects of Lithia Water on BDNF and Oxidative Stress Markers in Healthy Male Participants

NCT01257867 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 5

Last updated 2012-11-09

No results posted yet for this study

Summary

This study investigates the effects of daily use of lithia water on blood tests of neuronal oxidative stress, mood, and well-being. Lithia water is a type of pure spring water containing trace levels of lithium, which is a naturally occurring mineral. Neuronal oxidative stress is caused by normal chemical reactions in the human body that sometimes result in damage to brain cells. Participation in this study will last for 8 weeks and includes daily use of study water for drinking.

The primary objective of this pilot study is to test the hypothesis that, in healthy male participants, daily use of lithia water will improve neurogenesis and antioxidant capacity as measured by serum levels of brain-derived neurotrophic factor (BDNF) and oxidative stress markers. Secondary objectives will include examining self-reported changes in mood, cognition, and well-being.

Conditions

  • Oxidative Stress

Interventions

DIETARY_SUPPLEMENT

Lithia water

Oral intake of approximately 2 litres (2L) daily for 4 weeks

DIETARY_SUPPLEMENT

Natural spring water with negligible lithium levels

Oral intake of approximately 2 litres (2L) daily for 4 weeks

Sponsors & Collaborators

  • Aquaceutica Group

    collaborator UNKNOWN

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Raymond W Lam, MD, FRCPC · University of British Columbia

Study Design

Allocation
RANDOMIZED
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
19 Years
Max Age
35 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-03-31
Primary Completion
2012-10-31
Completion
2012-10-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01257867 on ClinicalTrials.gov