Nasopharyngeal Carcinoma (NPC) Axitinib
NCT01249547 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 37
Last updated 2017-04-25
Summary
This is an open-label, single arm, phase 2 clinical trial evaluating the activity and safety of single-agent axitinib in recurrent or metastatic NPC patients who failed at least one line of platinum based chemotherapy.
Conditions
- Recurrent or Metastatic NPC
Interventions
- DRUG
-
starting dose of 5 mg twice daily for 4 consecutive weeks without interruption.
Sponsors & Collaborators
-
Chinese University of Hong Kong
lead OTHER
Principal Investigators
-
Anthony TC Chan, MD, FRCP · Department of Clinical Oncology, The Chinese University of Hong Kong
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2010-12-31
- Primary Completion
- 2016-12-31
- Completion
- 2016-12-31
Countries
- Hong Kong
Study Locations
More Related Trials
-
A Phase II Study of TPF With PD-1 Inhibitor Induction Therapy for Locally Advanced Nasopharyngeal Carcinoma
NCT06781112 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Iparomlimab and Tuvonralimab Combined With Nimotuzumab in Recurrent or Metastatic NPC After First-line Treatment Failure: A Single-arm Phase IIa Clinical Trial
NCT07101744 ·Status: RECRUITING ·Phase: PHASE2
-
Anti-PD1 Monoclonal Antibody Combined With Nimotuzumab and Capecitabine in Patients With First-line Platinum-resistant Recurrent/Metastatic Nasopharyngeal Carcinoma
NCT06259721 ·Status: RECRUITING ·Phase: PHASE2
-
NEO-SPACE Trial: Pembrolizumab and Chemoradiation in Nasopharyngeal Cancer
NCT03734809 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of Anti-PD-1 AK105 in Patients With Metastatic Nasopharyngeal Carcinoma
NCT03866967 ·Status: COMPLETED ·Phase: PHASE2
-
SHR-1210 in Recurrent/Metastatic Nasopharyngeal Carcinoma Who Have Received Previous At Least Two Lines of Chemotherapy.
NCT03558191 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of a PD-1/CTLA-4 Bispecific Antibody AK104 in Patients With Metastatic Nasopharyngeal Carcinoma
NCT04220307 ·Status: COMPLETED ·Phase: PHASE2
-
Tislelizumab Combined With Chemotherapy Versus Chemotherapy Alone in Recurrent or Metastatic Nasopharyngeal Cancer (NPC)
NCT03924986 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Docetaxel and Cisplatin Combined With Nimotuzumab As First-Line Treatment in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma
NCT03708822 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of Non-Small Cell Lung Cancer (NSCLC) Patients Receiving Second-Line Nivolumab Monotherapy in Asia
NCT03195491 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Chemotherapy Combined With Nimotuzumab in Untreated Metastatic Nasopharyngeal Carcinoma
NCT01616849 ·Status: COMPLETED ·Phase: PHASE2
-
A Pilot Study of Autologous Ex Vivo Activated NK Cell Infusion in the Treatment of Metastatic Nasopharyngeal Carcinoma
NCT00717184 ·Status: COMPLETED ·Phase: PHASE1
-
Irinotecan Liposomes in Combination With Nituzumab for the Treatment of Recurrent/Metastatic Nasopharyngeal Carcinoma After Failure of First-Line or Higher Immunotherapy
NCT06414577 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Neoadjuvant Chemotherapy Combined With Finotonlimab in the Treatment of Locally Advanced Hypopharyngeal Carcinoma
NCT07248956 ·Status: RECRUITING ·Phase: PHASE2
-
Phase II Clinical Study to Compare the Efficacy and Safety of HLX07 + Serplulimab +Chemotherapy Versus Placebo + Serplulimab + Chemotherapy in First-Line Treatment of Patients With Recurrent or Metastatic NPC
NCT05513573 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Study to Evaluate the Efficacy and Safety of Immunotherapy With Axitinib in Advanced Collecting Duct Carcinoma
NCT06211114 ·Status: RECRUITING ·Phase: PHASE2
-
The Clinical Study of Apatinib Plus S1 for Patients With Advanced Non-squamous Head and Neck Cancer
NCT02943252 ·Status: UNKNOWN ·Phase: PHASE2
-
Capecitabine Plus Toripalimab Maintenance Therapy in Metastatic Nasopharyngeal Carcinoma After First-line Treatment
NCT05484375 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Dose-finding Study of Abraxane in Combination With Cisplatin to Treat Advanced Nasopharyngeal Carcinoma
NCT01735409 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Clinical Trial of Chemotherapy With Lobaplatin and 5-FU in Recurrent Local or Distant Advanced NPC.
NCT03210389 ·Status: UNKNOWN ·Phase: PHASE2
-
Stop and go Strategy as First-line Treatment for Widely Metastatic Nasopharyngeal Carcinoma
NCT06331845 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Selective Re-irradiation for Locally Advanced Recurrent NPC
NCT07332247 ·Status: RECRUITING ·Phase: PHASE2
-
Single-agent Capecitabine as Adjuvant Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma
NCT02958111 ·Status: UNKNOWN ·Phase: PHASE3
-
Targeted or Chemotherapy Combined With Immunotherapy Versus Chemotherapy for PD-1 Inhibitor Refractory R/M NPC
NCT05549466 ·Status: UNKNOWN ·Phase: PHASE2
-
Perioperative Chemotherapy and Immunotherapy for Locally Recurrent Nasopharyngeal Carcinoma
NCT07129772 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2