Axitinib is a small-molecule tyrosine kinase inhibitor developed for oncology and marketed as Inlyta. It is approved for renal cell carcinoma and is used as an oral targeted anti-cancer therapy. The medicine is prescription-only.
A 12-week supervised remote exercise program for patients with metastatic renal cell carcinoma undergoing immunotherapy showed significant improvements in health-related quality of life, fatigue, and symptom burden in a case series of 19 patients.
Ocular Therapeutix announced positive topline results from the SOL-1 Phase 3 superiority trial of AXPAXLI for wet age-related macular degeneration, meeting its primary endpoint with statistically significant improvements in vision outcomes compared to aflibercept.
Ocular Therapeutix's Axpaxli met its primary endpoint in the SOL-1 Phase 3 trial, showing superior vision maintenance compared to aflibercept in wet AMD patients. The company plans to pursue FDA approval based on the results.
Ocular Therapeutix announced positive topline results from SOL-1, its Phase 3 superiority trial of AXPAXLI for wet age-related macular degeneration, meeting primary and durability endpoints with high statistical significance.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07500831 |
Fasting-Mimicking Diet Combined With IO-TKI Combination Therapy in Patients With Metastatic Renal Cell Carcinoma |
NOT_YET_RECRUITING | NA |
| NCT07469683 |
An Open-label, Randomized Phase 2 Clinical Trial to Evaluate the Efficacy and Safety of the Combination Therapy of SLC-3010 and Axitinib Compared to Axitinib Monotherapy as a Second-line Treatment for Locally Advanced or Metastatic Clear Cell Renal Cell Carcinoma |
RECRUITING | PHASE2 |
| NCT07383441 |
Adding Biotherapy or Placebo to Standard Treatment for Advanced Kidney Cancer |
NOT_YET_RECRUITING | PHASE3 |
| NCT07227415 |
Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer |
RECRUITING | PHASE1/PHASE2 |
| NCT07123090 |
A Study of Sasanlimab, Palbociclib and Axitinib in Metastatic Renal Cell Carcinoma |
RECRUITING | PHASE2 |
| NCT06962787 |
A Study of BL-B01D1+TKI±Pembrolizumab in Patients With Locally Advanced or Metastatic Renal Cancer |
RECRUITING | PHASE2 |
| NCT06860386 |
Study of Adaptive Immunotherapy With VEGFR-TKI in Patients With Advanced RCC |
SUSPENDED | PHASE2 |
| NCT06690697 |
Combination of Toripalimab and JS004 Therapy for ccRCC |
RECRUITING | PHASE2 |
| NCT06364631 |
CARE1 Pragmatic Clinical Trial |
RECRUITING | PHASE3 |
| NCT06279403 |
Upfront Immune Checkpoint Inhibitors With Deferred Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma |
NOT_YET_RECRUITING | PHASE2 |
