Study of the Effect of Vitamin D as an Add-on Therapy to Corticosteroids in Asthma

Summary

The purpose of the study is to find out if taking vitamin D in addition to an asthma controller medication helps to prevent worsening of asthma symptoms and asthma attacks.

Conditions

• Asthma

Interventions

DRUG

Vitamin D3

vitamin D (100,000 IU loading dose followed by 4,000 IU/day)

DRUG

Ciclesonide

Low dose inhaled corticosteroid (80 mcg/puff two puffs twice daily)

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• Milton S. Hershey Medical Center

  lead OTHER

Principal Investigators

• David T. Mauger, PhD · Pennsylvania State University College of Medicine

• Elliot Israel, MD · Brigham and Women's Hospital

• Lewis Smith, MD · Northwestern Memorial Hospital

• Julian Solway, MD · University of Chicago

• James Moy, MD · Rush University Medical Center

• Richard Martin, MD · National Jewish Health

• Christine Sorkness, MD · University of Wisconsin, Madison

• Elizabeth Bade, MD · Aurora Sinai Medical Center

• Sally Wenzel, MD · University of Pittsburgh Medical Center

• James Chmiel, MD · Case Western Reserve University School of Medicine

• Mario Castro, MD · Washington University School of Medicine

• Homer Boushey, MD · University of California, San Francisco

• Monica Kraft, MD · Duke University

• Stephen Peters, MD · Wake Forest University Health Sciences

• W. Gerald Teague, MD · University of Virginia Health System

• Craig LaForce, MD · North Carolina Clinical Research

• Anne Fitzpatrick, MD · Emory University

• Jerry Krishnan, MD · University of Illinois at Chicago

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-04-30

Primary Completion

2014-01-31

Completion

2014-01-31

Countries

• United States

Study Locations