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Comparison of Efficacy of Different Dosages Vitamin K2

NCT01194778 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 82

Last updated 2010-09-03

No results posted yet for this study

Summary

Vitamin K is a group name for a number of compounds: K1 is present in chloroplasts in green vegetables, K2 is of microbial origin. Lactic bacteria produce a mixture of higher menaquinones, including menaquinone-7, menaquinone-8, and menaquinone-9. Nothing is known yet about the efficacy of bacterial K2 vitamins for in vivo K function (carboxylation of essential proteins). Therefore, this study was undertaken to study effects of different dosages of bacterial vitamin K2 on carboxylation of extrahepatic proteins.

Conditions

  • Carboxylation Level
  • Vitamin K-dependent Proteins

Interventions

DIETARY_SUPPLEMENT

placebo

1 placebo sachet per day containing only sucrose during 12 weeks

DIETARY_SUPPLEMENT

vitamin K1

15 µg vitamin K1 per day during 12 weeks

DIETARY_SUPPLEMENT

vitamin K2

15 µg vitamin K2 per day during 12 weeks

DIETARY_SUPPLEMENT

vitamin K2

30 µg vitamin K2 per day during 12 weeks

DIETARY_SUPPLEMENT

vitamin K2

45 µg vitamin K2 per day during 12 weeks

Sponsors & Collaborators

  • Maastricht University Medical Center

    lead OTHER

Principal Investigators

  • Cees Vermeer, PhD · VitaK BV Maastricht University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-10-31
Primary Completion
2010-02-28
Completion
2010-08-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01194778 on ClinicalTrials.gov