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Effect of Combined Exercise, Heat, and Quercetin Supplementation on Whole Body Stress Response

NCT01168739 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 9

Last updated 2024-03-12

No results posted yet for this study

Summary

The purpose of this study is to determine whether dietary quercetin supplementation effects thermotolerance and heat acclimation in human subjects exposed to exercise/heat stress.

Specific Aim I. To determine if quercetin in combination with repeated bouts of thermally stressful exercise will impact intestinal barrier function. The investigators will examine urinary lactulose excretion, plasma endotoxin,plasma quercetin, inflammatory cytokines (TNF-a \& Il-6), anti-inflammatory cytokines (Il-10), and HSP70 and HSF-1 content of peripheral blood mononuclear cells.

Specific Aim II. To determine whether quercetin's suppresses the ability of human subjects to acclimate to exercise/heat stress. The investigators will examine body temperatures, heart rates, physiological strain, sweat and plasma volume responses to standardized heat tolerance tests.

Conditions

  • Heat Acclimation and Thermotolerance

Interventions

DIETARY_SUPPLEMENT

Quercetin

2g/d dietary quercetin supplementation, 1g taken am; 1g taken pm

DIETARY_SUPPLEMENT

Placebo

Placebo, performed on same subjects as Quercetin Arm, used to compare results between conditions

Sponsors & Collaborators

  • Gatorade Sports and Science Institute

    collaborator OTHER

  • Quercegen Pharmaceuticals

    collaborator INDUSTRY

  • University of New Mexico

    lead OTHER

Principal Investigators

  • Pope L Moseley, MD · University of New Mexico, Professor and Chariman, Dpt of Internal Medicine

  • Matthew R. Kuennen, PhD · UNM Department of Health, Exercise and Sports Sciences and UNM Department of Internal Medicine

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
39 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-09-30
Primary Completion
2010-03-31
Completion
2010-03-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01168739 on ClinicalTrials.gov