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Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy

NCT01143467 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 26

Last updated 2017-10-06

No results posted yet for this study

Summary

Background:

\- Fatigue is a very common early and late side effect of cancer treatment, including radiation therapy. The cause of fatigue is poorly understood, making it hard to diagnose and treat. More research is necessary to understand why patients receiving cancer treatment experience fatigue. Changes in mitochondria, parts of body cells that help provide energy to the cell, may contribute to fatigue. Researchers are interested in looking at blood chemicals and mitochondrial genes of cancer patients to study those associated with fatigue.

Objectives:

\- To study the relationship between fatigue and the effects of cancer treatment.

Eligibility:

* Men at least 18 years of age who have been diagnosed with localized prostate cancer and are scheduled to receive external beam radiation therapy.
* Participants on study 09-NR-0088, Molecular-Genetic Correlates of Fatigue in Cancer Patients Receiving External Beam Radiation Therapy, are also eligible.

Design:

* This study requires three outpatient visits to the NIH Clinical Center.
* Participants will be seen before they start radiation treatment, at the middle of treatment, and at the end of treatment. Each visit will take less than 30 minutes to complete.
* Participants will complete questionnaires that ask about fatigue and depression.
* Participants will provide blood samples for research testing and potential HIV testing.
* No treatment will be provided as part of this protocol.

Conditions

Sponsors & Collaborators

  • National Institute of Nursing Research (NINR)

    lead NIH

Principal Investigators

  • Leorey N Saligan, C.R.N.P. · National Institute of Nursing Research (NINR)

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-05-24
Completion
2015-11-06

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01143467 on ClinicalTrials.gov