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Complement Factor H Haplotypes and Smoking in Age-related Macular Degeneration

NCT01115231 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 223

Last updated 2019-09-30

Study results available
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Summary

Risk factors for Age-related Macular Degeneration (AMD) involves genetic variations in the alternative pathway of complement inhibitor factor H. The complement system is part of the innate and adaptive immune system. Smoking is the only environmental factor known to increase the risk of Age-related Macular Degeneration (AMD). Using serum samples of Age-related Macular Degeneration (AMD) patients and controls the investigators will test the hypothesis that smoking increases Age-related Macular Degeneration (AMD) by increasing complement activation; and that this is positively correlated with known disease variations in the complement factor H (CFH) gene.

Conditions

  • Macular Degeneration

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Barbel M Rohrer, PhD · Ralph H. Johnson VA Medical Center, Charleston, SC

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-10-31
Primary Completion
2015-06-30
Completion
2016-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01115231 on ClinicalTrials.gov