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The Association of the Peripheral Retinal Changes and Genotypic Changes in Patients With Age Related Macular Degeneration

NCT03492853 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 310

Last updated 2018-04-10

No results posted yet for this study

Summary

Purpose: To examine the genotypes associated with the peripheral retinal phenotypic features in patients with age-related macular degeneration documented with wide-field imaging.

Design: Clinic-based case series study in Croatia. Participants: 160 patients \>50 years of age known to have early or advanced AMD and 150 subjects \>50 years of age without known AMD (controls) Methods: Both groups of patients were examined with ophthalmoscopy and OCT to confirm their classification. Posterior and peripheral fundus features were documented with Optos wide-field imaging (Optos P200MA, Optos Plc, Dunfermline, Scotland) and graded. DNA was extracted from blood samples and gene polymorphisms were evaluated for complement factor H (CFH) rs1061170 and rs1410996, age-related maculopathy susceptibility (ARMS2) rs10490924, high temperature requirement factor A1 (HtrA1) rs11200638, complement factor B (CFB) rs4151667 and rs641153, complement factor 2 (C2) rs9332739 and rs547154 and complement factor 3 (C3) rs2230199.

Conditions

  • Peripheral Retinal Degenerations, Age Related Macular Degeneration Polymorphisms

Interventions

GENETIC

DNA extraction and sequencing

DNA extraction from peripheral blood and KASP sequencing

Sponsors & Collaborators

  • University Hospital Sestre Milosrdnice

    lead OTHER

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-01-01
Primary Completion
2016-09-20
Completion
2016-12-29

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03492853 on ClinicalTrials.gov