A Study to Evaluate the Safety and Efficacy of RQC for AMD
NCT05062486 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 55
Last updated 2025-07-30
Summary
To evaluate the safety and efficacy of resveratrol, quercetin, and curcumin in combination (RQC) over 2 years in patients with age-related macular degeneration (AMD).
Conditions
- Age-related Macular Degeneration
Interventions
- DRUG
-
Resveratrol, Quercetin, Curcumin (RQC)
100 mg resveratrol, 120 mg quercetin, 1000 mg curcumin BID
- DRUG
-
Curcumin
1000 mg curcumin BID
Sponsors & Collaborators
-
Paul A Knepper, MD PhD
lead OTHER
Principal Investigators
-
Paul A Knepper, MD, PhD · Zaparackas Knepper, Ltd
-
Zibute Zaparackas, MD · Zaparackas Knepper, Ltd
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- SINGLE
- Model
- PARALLEL
Eligibility
- Min Age
- 50 Years
- Max Age
- 90 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-10-04
- Primary Completion
- 2024-11-07
- Completion
- 2024-11-07
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Safety and Efficacy of Anti-Oxidants and Anti-inflammatory Agents in Glaucoma and Diabetic Retinopathy
NCT02984813 ·Status: TERMINATED ·Phase: PHASE1
-
Effect of Omega-3 Fatty Acid Supplementation on Dry-AMD Progression
NCT05465252 ·Status: RECRUITING ·Phase: NA
-
Drusen Morphology Changes in Nonexudative Age-related Degeneration After Oral Antioxidants Supplementation
NCT02264938 ·Status: COMPLETED ·Phase: NA
-
The Influence of Lutein Supplements on Age-related Macular Degeneration
NCT01042860 ·Status: COMPLETED ·Phase: NA
-
Curcumin and Retinal Study
NCT05774704 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Carotenoid Supplementation and Retinal Health in Healthy Adults
NCT07314411 ·Status: RECRUITING ·Phase: NA
-
Oxidative Stress in Patients With Age-Related Macular Degeneration
NCT00465400 ·Status: COMPLETED
-
Lutein/Zeaxanthin and Omega-3 Supplementation in Persons Over Age 60
NCT00121589 ·Status: COMPLETED ·Phase: PHASE1
-
The Effect of Oral Administration of 9-cis β Carotene Rich Powder of the Alga Dunaliella Bardawil
NCT01680510 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Genotype-Phenotype Study of Patients With Plaquenil -Induced Retinal Toxicity, With Evaluation of the ABCA4 Gene
NCT01145196 ·Status: RECRUITING
-
Addition of 20mg/Day Zeaxanthin to Triple Therapy Treatment Options for Age Related Macular Degeneration (ARMD)
NCT01527435 ·Status: COMPLETED
-
Possible Effects of Supplement Therapy With Oral Phenolics on Cluster of Differentiation 163 (CD-163) Biomarker of Patients With Age-related Macular Degeneration
NCT05005884 ·Status: UNKNOWN ·Phase: PHASE1
-
The Role of the Gut Metagenome on the Development of Age Related Macular Degeneration (AMD)
NCT02438111 ·Status: UNKNOWN
-
Effect of Micronutrient Supplementation on the Intestinal Microbiota in Patients With Age-related Macular Degeneration - The Gut-Retina-axis Study
NCT06391411 ·Status: COMPLETED ·Phase: NA
-
Antioxidant Systems and Age-Related Macular Degeneration
NCT00668213 ·Status: COMPLETED
-
Effect of Saffron Supplementation on Macular Cone-mediated Function in Age-related Macular Degeneration
NCT00951288 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Morpho-functional Changes After Oral Supplementation of Antioxidants and Anti-inflammatory Treatment in Age-Related Macular Degeneration.
NCT03919019 ·Status: COMPLETED ·Phase: NA
-
Regional Kale as Source of Lutein and Zeaxanthin to Improve Vision of AMD-patients
NCT02136303 ·Status: UNKNOWN ·Phase: NA
-
Effects of Antioxidants on Human Macular Pigments
NCT00718653 ·Status: COMPLETED ·Phase: NA
-
The Zeaxanthin and Visual Function Study
NCT00564902 ·Status: COMPLETED ·Phase: NA
-
"Night Vision and Carotenoids"
NCT04741763 ·Status: COMPLETED ·Phase: NA
-
Lutein for Age-Related Macular Degeneration
NCT00006202 ·Status: COMPLETED ·Phase: PHASE2
-
Effect of Carotenoids Supplementation on Visual Function in Chinese Subjects
NCT06098677 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Age-related Macular Degeneration (AMD) and Cardiovascular Disease
NCT04087356 ·Status: UNKNOWN
-
Superoxide Dismutase (SOD) as Antioxidant Treatment OF Age Related Macular Degeneration (ARMD)
NCT00800995 ·Status: COMPLETED ·Phase: PHASE3