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Chitinases and Transforming Growth Factor Beta (TGFB) in Human Asthma

NCT01073410 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 23

Last updated 2022-02-01

No results posted yet for this study

Summary

The purpose of this study is to find out the roles of two specific gene families (the chitinase gene family and the TGFB family). We hypothesize that chitinases and TGFb pathway genes will be differentially expressed in the airways of non-asthmatic subjects and subjects with asthma. We further hypothesize that genetic variants in CHIT1, AMCase, and TGFb pathway genes that show associations with asthma and related phenotypes will change the expression and/or function of the protein of these genes in the airway in several ways, including the transcript numbers for full length genes and splice variants and, for the chitinase genes, the levels of chitinase activity in airway secretions.

Conditions

Sponsors & Collaborators

Principal Investigators

  • John G Fahy, MD · University of California, San Francisco

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-02-28
Primary Completion
2017-02-28
Completion
2021-04-30

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01073410 on ClinicalTrials.gov