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Role of Eosinophils in the Proliferation of Airway Smooth Muscle (ASM) Cells

NCT01082952 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 12

Last updated 2011-11-18

Study results available
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Summary

Being a key player in Asthma, eosinophils constitute a potential target to interfere with the series of biological events leading to Asthma pathogenesis. In this proposal, the investigators hypothesize that the interaction between eosinophils and airway smooth muscle cells (ASM) cells plays an important role in airway remodeling. Hence the investigators will investigate the role of eosinophils in enhancing ASM cells proliferation resulting in airways remodeling. The investigators will also investigate the mechanism behind this phenomenon. This will then pave the way for medical (drug) interference at one or several sites in order to prevent one of the main potential reasons behind airway remodeling, namely eosinophil-derived ASM proliferation.

Conditions

Sponsors & Collaborators

  • King Saud University

    lead OTHER

Principal Investigators

  • Saleh Al-Muhsen, MD · King Saud University

  • Rabih Halwani, PhD · King Saud University

Eligibility

Min Age
14 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-01-31
Primary Completion
2011-07-31
Completion
2011-07-31

Countries

  • Saudi Arabia

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01082952 on ClinicalTrials.gov