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Enhanced Firefighter Rehab Trial: The Role of Aspirin in Preventing Heat Stress Induced Platelet Activation

NCT01066923 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 124

Last updated 2017-11-13

Study results available
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Summary

The purpose of this study is to determine if aspirin taken by firefighters prevents platelets from becoming sticky when body temperature rises during work in protective clothing.

Conditions

  • Heat Stress Disorders

Interventions

DRUG

Daily aspirin (ASA)

Two weeks 82 mg aspirin taken orally prior to exercise protocol

OTHER

Active cooling

Active cooling to remediate heat stress following exercise by placing hands and forearms into cold water

DRUG

Acute aspirin (ASA)

325 mg chewable aspirin administered immediately following exercise

OTHER

Passive cooling

Removing protective garments for passive cooling following exercise

DRUG

Daily placebo

Placebo comparator for daily aspirin therapy

DRUG

Acute placebo

Placebo comparator for acute aspirin therapy

Sponsors & Collaborators

  • Federal Emergency Management Administration

    collaborator UNKNOWN

  • Eyemarker Systems, Inc

    collaborator INDUSTRY

  • Dave Hostler

    lead OTHER

Principal Investigators

  • David Hostler, PhD · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
49 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-02-28
Primary Completion
2011-06-30
Completion
2011-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01066923 on ClinicalTrials.gov