Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates

Summary

Introduction:

Based on single-center data, approximately 1 of every 3 newborns admitted to tertiary level neonatal intensive care units (NICU) develops acute kidney injury (AKI), and those with AKI have significantly worse outcomes. To stimulate discussion among researchers, the NIH NIDDK sponsored a workshop on neonatal AKI in April 2013. At that workshop, the group recognized the need to improve collaborations between neonatologists and nephrologists within and across centers. The investigators have created a multi-institutional, multi-disciplinary group, Neonatal Kidney Collaborative (NKC), in order to address the following critical needs identified at the workshop: AWAKEN is the inaugural study of this new collaboration.

1. Development of a standardized evidence-based definition of neonatal AKI
2. Evaluation of risk factors that predispose neonatal to AKI
3. Investigation into how fluid provision/ balance impacts biochemical and clinical outcomes

Conditions

• Acute Kidney Injury

Sponsors & Collaborators

• Children's Hospital Medical Center, Cincinnati

  collaborator OTHER

• George Washington University

  collaborator OTHER

• McGill University

  collaborator OTHER

• Albert Einstein College of Medicine

  collaborator OTHER

• University of Rochester

  collaborator OTHER

• University of British Columbia

  collaborator OTHER

• University of Iowa

  collaborator OTHER

• University of Michigan

  collaborator OTHER

• University of New Mexico

  collaborator OTHER

• University of Virginia

  collaborator OTHER

• University of Washington

  collaborator OTHER

• University of Miami

  collaborator OTHER

• Case Western Reserve University

  collaborator OTHER

• University of Kentucky

  collaborator OTHER

• Maimonides Medical Center

  collaborator OTHER

• Stony Brook University

  collaborator OTHER

• The Canberra Hospital

  collaborator OTHER

• Children's Hospital Colorado

  collaborator OTHER

• St. Louis Children's Hospital

  collaborator OTHER

• Baylor College of Medicine

  collaborator OTHER

• Medanta, The Medicity, India

  collaborator OTHER

• Ohio State University

  collaborator OTHER

• University of Alabama at Birmingham

  lead OTHER

Principal Investigators

• David Askenazi, MD · University of Alabama at Birmingham

Eligibility

Min Age

1 Minute

Max Age

2 Weeks

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-03-31

Primary Completion

2016-01-31

Completion

2016-03-31

Countries

• United States

Study Locations