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Pulmonary Arterial Pressure Response During Exercise

NCT00949195 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2011-07-21

No results posted yet for this study

Summary

Background:

The extent of increase in systolic pulmonary arterial pressure (PAPs) during exercise in patients with COPD is unpredictable from lung function data. The non-invasive assessment of pulmonary hemodynamics during exercise and flow-mediated vasodilatation measurement may give useful data in the rehabilitation of COPD patients.

Methods:

Patients with stable, severe COPD and healthy, age-matched subjects (H) perform semi supine echocardiography with PAPs measurement. COPD patients perform ramp protocol with gas exchange detection. Serum hsCRP level is also determined in COPD patients. Endothel dysfunction is detected by flow mediated vasodilation measurement after arm strangulation with Doppler ultrasonography.

Primary endpoint:

The degree of pulmonary artery systolic pressure change during exercise?

Secondary endpoint:

1. The degree of right ventricular function change during exercise?
2. Is endothel dysfunction manifested with pulmonary artery pressure rise?
3. What is the correlation between the systemic inflammatory marker hsCRP and the degree of pulmonary artery pressure rise?

Conditions

  • COPD Patients
  • Healthy Subjects
  • Semi-supine Echo (SSE)
  • Flow-mediated Vasodilatation (FMD)
  • High Sensitive C-reactive Protein (hsCRP)

Interventions

OTHER

Measure pulmonary artery pressure change during exercise

Semi-supine echocardiography test

OTHER

Pulmonary pressure response during exercise

Semi-supine echocardiography test

Sponsors & Collaborators

  • Szeged University

    lead OTHER

Principal Investigators

  • Attila Somfay, MD, PhD · Department of Pulmonology, Szeged University

Eligibility

Min Age
45 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-09-30
Primary Completion
2009-12-31
Completion
2011-12-31

Countries

  • Hungary

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00949195 on ClinicalTrials.gov