Lung Function, Exercise Capacity and Health-Related Quality of Life After Severe COVID-19

Summary

Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus (SARS-CoV-2) that can progress to severe disease requiring hospitalization and oxygen support in around14% of the cases and 5% require admission in intensive care unit. The medium and long-term impact in survivors of severe COVID-19 on lung function, exercise capacity and health-related quality of life remains to be determined.

Conditions

• COVID-19
• SARS-CoV-2 Infection

Interventions

DIAGNOSTIC_TEST

Lung Function tests

Spirometry before and after bronchodilator, lung volumes by body plethysmography, lung diffusion capacity of carbon monoxide (DLCO), respiratory system resistance by impulse oscillometry (IOS)

DIAGNOSTIC_TEST

Exercise capacity

6-minute walk test (6MWT distance)

DIAGNOSTIC_TEST

Exercise physiology

Cardiopulmonary exercise test (CPET)

DIAGNOSTIC_TEST

Health-related quality of life

Short-Form Health Survey Questionnaire (SF-36)

DIAGNOSTIC_TEST

Respiratory symptoms, symptoms of anxiety and depression, and post-traumatic stress screening

1. Adapted translation American Thoracic Society respiratory symptoms questionnaire; 2. Beck Anxiety Inventory (BAI) and Beck's depression Inventory (BDI); 3. Questionnaire for screening for post-traumatic stress symptoms (PTSD).

Sponsors & Collaborators

• Hospital de Clinicas de Porto Alegre

  collaborator OTHER

• Conselho Nacional de Desenvolvimento Científico e Tecnológico

  collaborator OTHER_GOV

• Hospital Moinhos de Vento

  collaborator OTHER

• Federal University of Health Science of Porto Alegre

  collaborator OTHER

• Universidade de Passo Fundo

  collaborator OTHER

• Hospital Nossa Senhora da Conceicao

  collaborator OTHER

• Federal University of Rio Grande do Sul

  lead OTHER

Principal Investigators

• Danilo C Berton, Dr · Universidade Federal do Rio Grande do Sul/Hospital de Clínicas de Porto Alegre

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-05-15

Primary Completion

2023-04-30

Completion

2023-07-30

Countries

• Brazil

Study Locations