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Investigation of the Effects of Exercise on Gene Expression

NCT00916019 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 6

Last updated 2009-06-16

No results posted yet for this study

Summary

The investigators have previously shown that mild exercise training at the level of lactate threshold (LT) intensity (60 min/day, 5 days/week) improves peripheral insulin sensitivity and insulin-independent glucose disposal of glucose effectiveness, without changes in body weight and body fat (Nishida et al, Diabetes Care, 2001; Nishida et al, Diabetes, 2004). Thus these beneficial effects are likely related to a number of adaptations that occur in skeletal muscle as response to exercise. In the current study, the investigators hypothesised that a single bout of mild exercise performed at LT would be a physiological stimulator of skeletal muscle PGC-1alpha gene, and the repetition of this exercise stimulating PGC-1alpha gene (i.e., training) for 12 weeks would induce coordinated increases in a large number of metabolic genes, as well as other genes potentially important in the prevention of insulin resistance and metabolic syndrome.

Conditions

  • Healthy

Interventions

OTHER

exercise training

60 min of low-intensity exercise, 5 days/week, 12 weeks

Sponsors & Collaborators

  • Fukuoka University

    lead OTHER

Principal Investigators

  • Hiroaki Tanaka, Ph.D. · Fukuoka University

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
19 Years
Max Age
32 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2002-07-31
Primary Completion
2007-12-31
Completion
2007-12-31

Countries

  • Japan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00916019 on ClinicalTrials.gov